July 16, 2020Open Access

In vivo miR-138-5p inhibition alleviates monocrotaline-induced pulmonary hypertension and normalizes pulmonary KCNK3 and SLC45A3 expression

HRHélène Le RibeuzCentre National de la Recherche Scientifique ACAudrey CourboulinInserm MGMaria‐Rosa GhignaInserm

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Abstract

We confirmed that in vivo inhibition of miR-138-5p reduces the development of PH in experimental MCT-PH. The possible curative mechanisms involve at least the normalization of lung KCNK3 as well as SLC45A3 expression.

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