Mammalian heart model of chronic cardiovascular stress
Healthy mammalian heart
Transcriptional changes and cellular drivers of cardiac fibrosis and hypertrophysurrogate
Provides a high-resolution transcriptomic resource identifying early cellular and molecular drivers of cardiac fibrosis and hypertrophy during chronic stress.
These results offer a valuable resource for exploring the cardiac cellular landscape in health and after chronic cardiovascular stress. These data provide insights into the cellular and molecular mechanisms that promote pathological remodeling of the mammalian heart, highlighting early transcriptional changes that precede chronic cardiac fibrosis.
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Micheal A. McLellan
Boston University
Daniel A. Skelly
Jackson Laboratory
Malathi S.I. Dona
Baker Heart and Diabetes Institute
Circulation
Tufts University
La Trobe University
Jackson Laboratory
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McLellan et al. (Thu,) studied this question.
synapsesocial.com/papers/69de84e7bf539e2270558e35 — DOI: https://doi.org/10.1161/circulationaha.119.045115