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Temperature-induced mineral alterations are extensively used in traditional pharmaceutical industry. Studies on the traditional heating methods for enhancing pharmaceutical properties and on the toxicity of mineral-based medicines are limited. This study focuses on the effect of thermal alterations on mineralogical and chemical changes of biotite with respect to two traditional drugs (Abhrak Bhasma and Abhrak Chendhuram). Samples of the drugs and heat-treated and untreated biotite minerals were characterized using X-ray diffraction analysis, Fourier-transform infra-red spectroscopy, thermogravimetric analysis and differential scanning calorimetry. Total and water-soluble cation concentrations of drugs were measured using atomic absorption spectrometry. The study reveals that the degree of collapsing the biotite structure increased with the thermal oxidation process that produced nanoparticles of crystalline and amorphous iron oxides and secondary silicates. The thermal products of biotite had nano-crystallinity and high water solubility. The study suggests that modern pharmaceuticals can be developed from mineral-based traditional drugs.
Wijenayake et al. (Wed,) studied this question.
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