The bag-mediated filtration system significantly increased the detection of Sabin-like poliovirus type 1 in environmental samples compared to the standard WHO two-phase separation method (OR 2.38).
Observational (n=133)
Yes
The BMFS offers comparable or improved poliovirus detection for environmental surveillance relative to the standard WHO two-phase method.
Effect estimate: OR 2.38 (95% CI 1.04-5.43)
Absolute Event Rate: 24.8% vs 16.5%
p-value: p=0.036
AIMS: This study compared the bag-mediated filtration system (BMFS) and standard WHO two-phase separation methods for poliovirus (PV) environmental surveillance, examined factors impacting PV detection and monitored Sabin-like (SL) PV type 2 presence with withdrawal of oral polio vaccine type 2 (OPV2) in April 2016. METHODS AND RESULTS: ). CONCLUSIONS: Poliovirus was detected at higher rates with the BMFS, a method that includes a secondary concentration step, than using the standard WHO two-phase method. SL2 disappearance from the environment was commensurate with OPV2 withdrawal. SIGNIFICANCE AND IMPACT OF THE STUDY: The BMFS offers comparable or improved PV detection under the conditions in this study, relative to the two-phase method.
Fagnant-Sperati et al. (Mon,) conducted a observational in Poliovirus environmental surveillance (n=133). Bag-mediated filtration system (BMFS) vs. Standard WHO two-phase separation method was evaluated on Detection of Sabin-like poliovirus type 1 (SL1) (OR 2.38, 95% CI 1.04-5.43, p=0.036). The bag-mediated filtration system significantly increased the detection of Sabin-like poliovirus type 1 in environmental samples compared to the standard WHO two-phase separation method (OR 2.38).
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