Acute intermittent hypercapnic hypoxia increased minute ventilation by 4.6 L/min from baseline during recovery (P<0.01), demonstrating ventilatory long-term facilitation in healthy humans.
Mean Difference: 4.6
p-value: p=<0.01
Key points Ventilatory long‐term facilitation (vLTF) refers to respiratory neuroplasticity that develops following intermittent hypoxia in both healthy and clinical populations. A sustained hypercapnic background is argued to be required for full vLTF expression in humans. We determined whether acute intermittent hypercapnic hypoxia elicits vLTF during isocapnic‐normoxic recovery in healthy males and females. We further assessed whether tonic peripheral chemoreflex drive is necessary and contributes to the expression of vLTF. Following 40 min of intermittent hypercapnic hypoxia, minute ventilation was increased throughout 50 min of isocapnic‐normoxic recovery. Inhibition of peripheral chemoreflex drive with hyperoxia attenuated the magnitude of vLTF. Males and females achieve vLTF through different respiratory recruitment patterns. Abstract Ventilatory long‐term facilitation (vLTF) refers to respiratory neuroplasticity that manifests as increased minute ventilation ( ) following intermittent hypoxia. In humans, hypercapnia sustained throughout intermittent hypoxia and recovery is considered necessary for vLTF expression. We examined whether acute intermittent hypercapnic hypoxia (IHH) induces vLTF, and if peripheral chemoreflex drive contributes to vLTF throughout isocapnic‐normoxic recovery. In 19 individuals (9 females, age: 22 ± 3 years; mean ± SD), measurements of tidal volume ( V T ), breathing frequency ( f B ), , and end‐tidal gases ( and ), were made at baseline, during IHH and 50 min of recovery. Totalling 40 min, IHH included 1 min intervals of 40 s hypercapnic hypoxia (target = 50 mmHg and = +4 mmHg above baseline) and 20 s normoxia. During baseline and recovery, dynamic end‐tidal forcing maintained resting and and delivered 1 min of hyperoxia ( = 355 ± 7 mmHg) every 5 min. The depression in during hyperoxia was considered an index of peripheral chemoreflex drive. Throughout recovery was increased 4.6 ± 3.7 l min −1 from baseline ( P < 0.01). Hyperoxia depressed at baseline, and augmented depression was evident following IHH (Δ = −0.8 ± 0.9 vs . −1.7 ± 1.3 l min −1 , respectively, P < 0.01). The vLTF was similar between sexes ( P = 0.15), but males had larger increases in V T than females (sex‐by‐time interaction, P = 0.03), and females tended to increase f B ( P = 0.09). During isocapnic‐normoxic recovery following IHH: (1) vLTF is expressed in healthy humans; (2) vLTF expression is attenuated but not abolished with peripheral chemoreflex inhibition by hyperoxia, suggesting a contribution from central nervous pathways in vLTF expression; and (3) males and females develop similar vLTF through different ventilatory recruitment strategies.
Vermeulen et al. (Mon,) conducted a other in Healthy (n=19). Acute intermittent hypercapnic hypoxia vs. Baseline was evaluated on Minute ventilation increase from baseline during recovery (MD 4.6, p=<0.01). Acute intermittent hypercapnic hypoxia increased minute ventilation by 4.6 L/min from baseline during recovery (P<0.01), demonstrating ventilatory long-term facilitation in healthy humans.