Patients with myocardial infarction aged <50 years had a significantly higher rate of having ≥2 relatives with premature atherosclerosis compared to older MI patients (10.8% vs 2.9%).
Case-Control (n=720)
No
Is a family history of premature cardiovascular disease associated with a younger age of myocardial infarction?
A family history of premature atherosclerosis involving both first- and second-degree relatives is strongly associated with a younger age of myocardial infarction, highlighting its value in cardiovascular risk evaluation for young people.
Absolute Event Rate: 10.8% vs 2.9%
p-value: p=<0.0001
BACKGROUND: Premature coronary artery disease is one of the most pressing global issues in modern cardiology. The aim of the study was to investigate the role of family history of premature cardiovascular disease (CVD) in patients aged < 50 years with myocardial infarction (MI) compared to that in patients aged ≥50 years with MI and to that in young people without MI (no-MI < 50). METHODS: The studied group (MI < 50) consisted of 240 patients aged 26-49 years with MI. The control groups consisted of 240 patients (MI ≥ 50) with MI aged 50-92 years and 240 healthy people aged 30-49 years without a history of MI (no-MI < 50). RESULTS: There were statistically significant differences between the MI < 50 and MI ≥ 50 and no-MI < 50 groups regarding the family history of premature MI/ischaemic stroke and the percentage of patients with ≥2 relatives affected (10.8, 2.9, and 3.7%, respectively; p < 0.0001). There was a statistically significant difference in the patient age at the first MI occurrence among patients without a family history of premature CVD, those with 1 affected relative, and those with ≥2 affected first-degree relatives (56.6, 48.6 and 41.8 years, respectively) as well as those with affected first- and second-degree relatives (56.5, 50.7 and 47.0 years, respectively). CONCLUSIONS: A younger age of patients with myocardial infarction is associated with a higher number of relatives with a history of premature MI/ischaemic stroke. Thus, the family history of premature atherosclerosis involving not only first- but also second-degree relatives seems to be a valuable factor in CVD risk evaluation in young people.
Ambroziak et al. (Thu,) conducted a case-control in Myocardial infarction (n=720). Family history of premature cardiovascular disease vs. No family history of premature cardiovascular disease was evaluated on Percentage of patients with ≥2 relatives affected by premature MI/ischaemic stroke (p=<0.0001). Patients with myocardial infarction aged <50 years had a significantly higher rate of having ≥2 relatives with premature atherosclerosis compared to older MI patients (10.8% vs 2.9%).