Predictive role of early recurrence of atrial fibrillation after cryoballoon ablation

Q: What is the clinical evidence from this study?

Study design: Cohort. Population: Atrial fibrillation (n=3681). Intervention: Early recurrence of atrial fibrillation (ERAF) vs. No ERAF. Primary outcome: Freedom from AF recurrence at 24-month follow-up (p=<0.001).

Key Result

Early recurrence of atrial fibrillation after cryoballoon ablation was associated with lower freedom from AF recurrence at 24 months compared to no early recurrence (25.7% vs 64.8%; P<0.001).

Study Design

Type

Cohort (n=3,681)

Structured PICO

Does early recurrence of atrial fibrillation predict long-term AF recurrence in patients undergoing cryoballoon ablation?

Population

3,681 consecutive patients with atrial fibrillation (74.3% paroxysmal) undergoing cryoballoon ablation, followed for a mean of 16.8 months.

Exposure

Cryoballoon (CB) ablation

Comparator

Patients without early recurrence of atrial fibrillation (ERAF) during the 3-month blanking period

Outcome

Long-term atrial fibrillation recurrence (lasting at least 30 s) after the 3-month blanking periodhard clinical

Early recurrence of atrial fibrillation during the blanking period after cryoballoon ablation is a strong predictor of long-term AF recurrence.

Main Result

Absolute Event Rate: 25.7% vs 64.8%

p-value: p=<0.001

Abstract

AIMS: The aims of this study were to determine the rate and the predictors of early recurrences of atrial fibrillation (ERAF) after cryoballoon (CB) ablation and to evaluate whether ERAF correlate with the long-term outcome. METHODS AND RESULTS: Three thousand, six hundred, and eighty-one consecutive patients (59.9 ± 10.5 years, female 26.5%, and 74.3% paroxysmal AF) were included in the analysis. Atrial fibrillation recurrence, lasting at least 30 s, was collected during and after the 3-month blanking period. Three-hundred and sixteen patients (8.6%) (Group A) had ERAF during the blanking period, and 3365 patients (Group B) had no ERAF. Persistent AF and number of tested anti-arrhythmic drugs ≥2 resulted as significant predictors of ERAF. After a mean follow-up of 16.8 ± 16.4 months, 923/3681 (25%) patients had at least one AF recurrence. The observed freedom from AF recurrence, at 24-month follow-up from procedure, was 25.7% and 64.8% in Groups A and B, respectively (P 30 days after the ablation.

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Cite This Study

Stabile et al. (Sat,) conducted a cohort in Atrial fibrillation (n=3,681). Early recurrence of atrial fibrillation (ERAF) vs. No ERAF was evaluated on Freedom from AF recurrence at 24-month follow-up (p=<0.001). Early recurrence of atrial fibrillation after cryoballoon ablation was associated with lower freedom from AF recurrence at 24 months compared to no early recurrence (25.7% vs 64.8%; P<0.001).

synapsesocial.com/papers/6a4c42e8028ea97264ab7775 https://doi.org/https://doi.org/10.1093/europace/euaa239

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