Cannabidiol may have proarrhythmic effects via hERG and potassium channel inhibition, particularly when its metabolism is impaired or repolarization reserve is weakened.
values after CBD smoking and oral intake, our results raise the possibility that hERG and potassium channel inhibition might have a role in the possible proarrhythmic adverse effects of cannabinoids in situations where metabolism of CBD impaired and/or the repolarization reserve is weakened.
Orvos et al. (Wed,) studied this question.
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