Autophagy is a complex process of intracellular degradation of senescent or malfunctioning organelles. Dysregulated autophagy is associated with certain cancers, neurodegenerative diseases, immune dysfunction, and aging. Therapies aimed at regulating autophagy are being developed.

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Cite This Study

Mizushima et al. (Wed,) studied this question.

synapsesocial.com/papers/69d70c1fe328128020aa8b4d https://doi.org/https://doi.org/10.1056/nejmra2022774

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Tumor Vessel Normalization by Chloroquine Independent of Autophagy2014 · 412 citations
2Autophagy-deficient mice develop multiple liver tumors2011 · 1,316 citations
3Phase Separation, Transition, and Autophagic Degradation of Proteins in Development and Pathogenesis2019 · 124 citations
4Autophagy and Lipid Droplets in the Liver2015 · 330 citations
5Deciphering the Molecular Signals of PINK1/Parkin Mitophagy2016 · 717 citations

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Tumor Vessel Normalization by Chloroquine Independent of Autophagy2014 · 412 citations
2Autophagy-deficient mice develop multiple liver tumors2011 · 1,316 citations
3Phase Separation, Transition, and Autophagic Degradation of Proteins in Development and Pathogenesis2019 · 124 citations
4Autophagy and Lipid Droplets in the Liver2015 · 330 citations
5Deciphering the Molecular Signals of PINK1/Parkin Mitophagy2016 · 717 citations