Acute and chronic psychological stress is linked to enhanced risk of thrombosis, impacting both healthy individuals and cardiovascular disease patients.
How do acute and chronic psychological stress affect thrombosis risk and underlying cellular mechanisms in healthy individuals and cardiovascular disease patients?
This review outlines the cellular and molecular mechanisms linking acute and chronic psychological stress to thrombosis in both healthy individuals and patients with cardiovascular disease.
Absolute Event Rate: 0% vs 0%
Psychological stress induces different alterations in the organism in order to maintain homeostasis, including changes in hematopoiesis and hemostasis. In particular, stress-induced hyper activation of the autonomic nervous system and hypothalamic–pituitary–adrenal axis can trigger cellular and molecular alterations in platelets, coagulation factors, endothelial function, redox balance, and sterile inflammatory response. For this reason, mental stress is reported to enhance the risk of cardiovascular disease (CVD). However, contrasting results are often found in the literature considering differences in the response to acute or chronic stress and the health condition of the population analyzed. Since thrombosis is the most common underlying pathology of CVDs, the comprehension of the mechanisms at the basis of the association between stress and this pathology is highly valuable. The aim of this work is to give a comprehensive review of the studies focused on the role of acute and chronic stress in both healthy individuals and CVD patients, focusing on the cellular and molecular mechanisms underlying the relationship between stress and thrombosis.
Sandrini et al. (Thu,) reported a other. Acute and chronic psychological stress is linked to enhanced risk of thrombosis, impacting both healthy individuals and cardiovascular disease patients.