Ejection fraction category (reduced, mid-range, or preserved) in acute heart failure patients was not significantly associated with 12-month all-cause mortality (P=0.220) or re-hospitalization.
Observational (n=4,577)
Yes
In a Middle Eastern registry of acute heart failure patients, mortality and rehospitalization rates at 3 and 12 months were similar across reduced, mid-range, and preserved ejection fraction groups.
p-value: p=0.188
Background: Heart failure (HF) burden in the developing world is not well quantified. Objectives: The objective is to evaluate the demographics and outcomes of acute HF patients with reduced ejection fraction (EF) (<40%) (HFr EF), HF with midrange EF (40%–49%) (HFmr EF) and HF with preserved EF (≥50%) (HFp EF) in the Arabian Gulf. Methods: Gulf CARE registry analyzed 4577 HF patients admitted to 47 hospitals in seven Middle Eastern countries (Kuwait, Oman, Qatar, Saudi Arabia, United Arab Emirates, Bahrain, and Yemen.) Analyses were performed using multivariate statistical techniques. Results: The overall median age was 60 (50–70) years and 63% (n = 2887) were male. The most prominent comorbidities included hypertension (61%; n = 2783), coronary artery disease (60%; n = 2762), and diabetes mellitus (49%; n = 2258). A total of 59% (n = 2683) of the patients had HFr EF, 21% (n = 962) had HFmr EF and 20% (n = 932) had HFp EF. Compared to those with HFr EF, patients with HFmr EF and HFp EF were more likely to be associated with hypertension (57% vs. 67% vs. 64%; P < 0.001), diabetes mellitus (47% vs. 57% vs. 51%; P = 0.002), and higher systolic blood pressure (133 vs. 143 vs. 143 mmHg; P < 0.001). Multiple logistic regressions demonstrated that there were no significant differences among the groups with regards to the 3-month (overall adjusted P value; P = 0.188) and 12-month (P = 0.220) cumulative all-cause mortality. The results also indicated that there were no significant differences among the groups with regards to the 3-month (P = 0.117) and 12-month (P = 0.244) re-hospitalization rates for HF. Conclusions: No significant differences among the groups with regards to 3-month and 12-month all-cause mortality and re-hospitalization rates for HF were observed between the groups in the Arabian Gulf.
Rajan et al. (Wed,) conducted a observational in Acute heart failure (n=4,577). Heart failure with mid-range and preserved ejection fraction vs. Heart failure with reduced ejection fraction was evaluated on 3-month and 12-month cumulative all-cause mortality and re-hospitalization for HF (p=0.188). Ejection fraction category (reduced, mid-range, or preserved) in acute heart failure patients was not significantly associated with 12-month all-cause mortality (P=0.220) or re-hospitalization.