Does sacubitril/valsartan increase ANP concentrations and is this associated with reverse cardiac remodeling in patients with HFrEF?
Initiation of sacubitril/valsartan in HFrEF doubles ANP concentrations, an early increase that correlates with the magnitude of subsequent reverse cardiac remodeling.
Concentrations of ANP doubled after initiation of sacubitril/valsartan in patients with HFrEF. Larger early increases in ANP were associated with a greater magnitude of subsequent reverse cardiac remodeling. (Effects of Sacubitril/Valsartan Therapy on Biomarkers, Myocardial Remodeling and Outcomes PROVE-HF; NCT02887183).
Murphy et al. (Wed,) studied this question.