Non-invasive right ventricular global constructive work (RVGCW) moderately correlated with invasively measured stroke volume (r = 0.63, P = 0.002) and stroke volume index (r = 0.59, P = 0.004).
Observational (n=44)
Does non-invasive right ventricular myocardial work (RVMW) correlate with invasive right heart catheterization indices in patients with HFrEF?
Non-invasive right ventricular global constructive work (RVGCW) correlates moderately with invasive stroke volume, offering a potential novel echocardiographic marker for RV systolic function in HFrEF.
Effect estimate: r = 0.63
p-value: p=0.002
AIMS: Right ventricular myocardial work (RVMW) is a novel method for non-invasive assessment of right ventricular (RV) function utilizing RV pressure-strain loops. This study aimed to explore the relationship between RVMW and invasive indices of right heart catheterization (RHC) in a cohort of patients with heart failure with reduced left ventricular ejection fraction (HFrEF), and to compare values of RVMW with those of a group of patients without cardiovascular disease. METHODS AND RESULTS: Non-invasive analysis of RVMW was performed in 22 HFrEF patients median age 63 (59-67) years who underwent echocardiography and invasive RHC within 48 h. Conventional RV functional measurements, RV global constructive work (RVGCW), RV global work index (RVGWI), RV global wasted work (RVGWW), and RV global work efficiency (RVGWE) were analysed and compared with invasively measured stroke volume and stroke volume index. Non-invasive analysis of RVMW was also performed in 22 patients without cardiovascular disease to allow for comparison between groups. None of the conventional echocardiographic parameters of RV systolic function were significantly correlated with stroke volume or stroke volume index. In contrast, one of the novel indices derived non-invasively by pressure-strain loops, RVGCW, demonstrated a moderate correlation with invasively measured stroke volume and stroke volume index (r = 0.63, P = 0.002 and r = 0.59, P = 0.004, respectively). RVGWI, RVGCW, and RVGWE were significantly lower in patients with HFrEF compared to a healthy cohort, while values of RVGWW were significantly higher. CONCLUSION: RVGCW is a novel parameter that provides an integrative analysis of RV systolic function and correlates more closely with invasively measured stroke volume and stroke volume index than other standard echocardiographic parameters.
Butcher et al. (Fri,) conducted a observational in Heart failure with reduced left ventricular ejection fraction (HFrEF) (n=44). Right ventricular myocardial work (RVMW) assessment vs. Invasive right heart catheterization / Healthy cohort was evaluated on Correlation of RV global constructive work (RVGCW) with invasively measured stroke volume (r = 0.63, p=0.002). Non-invasive right ventricular global constructive work (RVGCW) moderately correlated with invasively measured stroke volume (r = 0.63, P = 0.002) and stroke volume index (r = 0.59, P = 0.004).