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Vaccination with early ferroptotic cancer cells induces efficient antitumor immunity | Synapse

November 1, 2020Open Access

Vaccination with early ferroptotic cancer cells induces efficient antitumor immunity

IEIuliia EfimovaGhent University ECElena CatanzaroGhent University LMLouis Van der MeerenGhent University

Key Points

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Abstract

These results pave the way for the development of new therapeutic strategies for cancers based on induction of ferroptosis, and thus broadens the current concept of immunogenic cell death and opens the door for the development of new strategies in cancer immunotherapy.

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Cite This Study

Efimova et al. (Sun,) studied this question.

synapsesocial.com/papers/69dc23e5b2c6945192751bd0 https://doi.org/https://doi.org/10.1136/jitc-2020-001369

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1A Role for Oxidative Stress in Apoptosis: Oxidation and Externalization of Phosphatidylserine Is Required for Macrophage Clearance of Cells Undergoing Fas-Mediated Apoptosis2002 · 258 citations
2Efficient T Cell Activation via a Toll-Interleukin 1 Receptor-Independent Pathway2006 · 92 citations
3Necroptosis in development, inflammation and disease2016 · 1,027 citations
4Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death2012 · 18,428 citations
5Vaccination with Necroptotic Cancer Cells Induces Efficient Anti-tumor Immunity2016 · 452 citations