Human immunodeficiency virus infection was associated with greater myocardial fibrosis by extracellular volume fraction compared with uninfected controls (absolute difference 1.2%; 95% CI 0.1-2.3).
Cross-Sectional (n=229)
Does HIV infection increase myocardial fibrosis and NT-proBNP levels in persons free of known cardiovascular disease?
HIV infection is associated with greater myocardial fibrosis and elevated NT-proBNP, particularly among women, suggesting a mechanism for increased heart failure risk in this population.
Mean Difference: 1.2 (95% CI 0.1–2.3)
BACKGROUND: Heart failure is a prominent cardiovascular disease (CVD) manifestation in sub-Sarahan Africa. Myocardial fibrosis is a central feature of heart failure that we aimed to characterize among persons with human immunodeficiency virus (PWH) in South Africa. METHODS: Cardiovascular magnetic resonance (CMR) imaging was performed among PWH with viral suppression and uninfected controls, both free of known CVD. Plasma levels of N-terminal pro B-type natriuretic peptide (NT-proBNP) were measured. Comparisons by human immunodeficiency virus (HIV) status were made using linear and logistic regression, adjusted for age, sex, and hypertension. RESULTS: One hundred thirty-four PWH and 95 uninfected persons completed CMR imaging; age was 50 and 49 years, with 63% and 67% female, respectively. Compared with controls, PWH had greater myocardial fibrosis by extracellular volume fraction (ECV absolute difference, 1.2%; 95% confidence interval CI, 0.1-2.3). In subgroup analyses, the effect of HIV status on ECV was more prominent among women. Women (vs controls) were also more likely to have elevated NT-proBNP levels (>125 pg/mL; odds ratio, 2.4; 95% CI, 1.0-6.0). Among all PWH, an elevated NT-proBNP level was associated with higher ECV (3.4% higher; 95% CI, 1.3-5.5). CONCLUSIONS: Human immunodeficiency virus disease may contribute to myocardial fibrosis, with an effect more prominent among women. Research is needed to understand heart failure risk among PWH within sub-Saharan Africa.
Shuldiner et al. (Mon,) conducted a cross-sectional in Human immunodeficiency virus (HIV) (n=229). Human immunodeficiency virus (HIV) infection vs. Uninfected controls was evaluated on Myocardial fibrosis by extracellular volume fraction (ECV) (Absolute difference 1.2%, 95% CI 0.1-2.3). Human immunodeficiency virus infection was associated with greater myocardial fibrosis by extracellular volume fraction compared with uninfected controls (absolute difference 1.2%; 95% CI 0.1-2.3).
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