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In order to implement radiotherapy based on a laser accelerator, it is necessary to precisely control the spatial distribution and energy spectrum of the proton beams to meet the requirements of the radiation dose distribution in the three-dimensional biological target. A compact laser plasma accelerator has been built at Peking University, which can reliably generate and transport MeV-energy protons with a specified energy onto the irradiation platform. In this paper, we discuss several technologies for the accurate control of a laser-accelerated proton beam with large divergence angle and broad energy spread, including the determination of the beam source position with micron accuracy, a tuning algorithm for the transport line which we refer to as ``matching-image-point two-dimensional energy analysis'' to realize accurate energy selection, and the control of beam distribution uniformity. In the prototype experiment with low energy protons and 0.5-Hz irradiation rate, a tailored energy deposition is demonstrated, which shows the potential feasibility of future irradiation based on laser-accelerated proton beams.
Zhu et al. (Mon,) studied this question.