High levels of physical activity were associated with a 45% lower risk of instant fatal myocardial infarction compared to a sedentary lifestyle (OR 0.55).
Meta-Analysis (n=28,140)
Yes
Does a higher past level of physical activity reduce instant and 28-day case fatality in patients with an incident myocardial infarction?
Moderate-to-high levels of past physical activity are associated with a significantly lower risk of instant and 28-day mortality following an incident myocardial infarction.
Effect estimate: OR 0.55 (95% CI 0.40-0.76)
AIMS: To assess the association between past level of physical activity (PA) and risk for death during the acute phase of myocardial infarction (MI) in a pooled analysis of cohort studies. METHODS AND RESULTS: European cohorts including participants with a baseline assessment of PA, conventional cardiovascular (CV) risk factors, and available follow-up on MI and death were eligible. Patients with an incident MI were included. Leisure-time PA was grouped as sedentary (32 MET-hours) based on calculated net weekly energy expenditure. The main outcome measures were instant and 28-day case fatality of MI. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using multivariate random-effects models. Adjustments for age, sex, CV risk factors, alcohol consumption, and socioeconomic status were made. From 10 cohorts including a total of 1 495 254 participants, 28 140 patients with an incident MI comprised the study population. A total of 4976 (17.7%) died within 28 days-of these 3101 (62.3%) were classified as instant fatal MI. Compared with sedentary individuals, those with a higher level of PA had lower adjusted odds of instant fatal MI: low PA OR, 0.79 (95% CI, 0.60-1.04), moderate PA 0.67 (0.51-0.89), and high PA 0.55 (0.40-0.76). Similar results were found for 28-day fatal MI: low PA 0.85 (0.71-1.03), moderate PA 0.64 (0.51-0.80), and high PA 0.72 (0.51-1.00). A low-to-moderate degree of heterogeneity was detected in the analysis of instant fatal MI (I2 = 47.3%), but not in that of 28-day fatal MI (I2 = 0.0%). CONCLUSION: A moderate-to-high level of PA was associated with a lower risk of instant and 28-day death in relation to a MI.
Hansen et al. (Fri,) conducted a meta-analysis in Myocardial Infarction (n=28,140). High physical activity vs. Sedentary (<7 MET-hours per week) was evaluated on Instant fatal MI (OR 0.55, 95% CI 0.40-0.76). High levels of physical activity were associated with a 45% lower risk of instant fatal myocardial infarction compared to a sedentary lifestyle (OR 0.55).
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