Does higher plasma renin activity predict mortality or cardiovascular incidence in patients with acute coronary syndromes?
Higher plasma renin activity is an independent predictor of 3-year all-cause mortality in patients with acute coronary syndromes, though this association diminishes over longer follow-up.
Higher PRA was a significant independent predictor of all-cause mortality after three years, but not at long-term follow-up and not significantly associated with cardiovascular incidence. The renin-angiotensin-system pathophysiology is of great interest, not least due to its association with the COVID-19 pandemic. Our findings indicate a need for further research on the prognostic/predictive aspects of the renin-angiotensin-system in ACS.
Hartford et al. (Tue,) studied this question.