Does quantification of myocardial blood flow with CZT dynamic SPECT imaging improve diagnostic efficiency for CAD compared to traditional semi-quantitative gated MPI in patients with suspected or known CAD?
Quantitative CZT dynamic SPECT imaging offers superior diagnostic accuracy and specificity for detecting coronary artery disease compared to traditional semi-quantitative methods.
BACKGROUND: Myocardial blood flow (MBF) quantitation with cadmium-zinc-telluride (CZT) dynamic single-photon emission computed tomography (SPECT) is being increasingly investigated toward clinical utilization. METHODS: In this prospective study, forty-nine patients with suspected or known coronary artery disease (CAD) underwent a rest/adenosine triphosphate (ATP) stress dynamic and routine gated myocardial perfusion imaging (MPI) by CZT SPECT and then received coronary angiography (CAG). Quantitative diagnosis from the dynamic SPECT and a flow diagram was automatically obtained by the dedicated software and compared with the result of semi-quantitative analysis with gated MPI using the angiographic stenosis as the reference standard. RESULTS: 63.3%) for the criteria of ≥75% stenosis on CAG (all P<0.05) with optimal critical values as 1.71 and 1.15 mL/min/g. There was no significant difference between sMBF and MFR. CONCLUSIONS: The diagnostic efficiency by using the quantitative method of CZT dynamic SPECT imaging is superior to traditional semi-quantitative gated MPI for the diagnosis of CAD, which improved the diagnostic specificity and accuracy when the critical was stenosis ≥50%.
Wang et al. (Mon,) studied this question.