The abstract outlines the study objectives to evaluate the prognostic role of molecular and genetic factors in anthracycline-induced cardiotoxicity, but reports no results.
Observational
Do molecular and genetic factors predict the development of endothelial dysfunction and anthracycline-induced cardiotoxicity in women without cardiovascular diseases?
This study aims to evaluate the prognostic role of endothelin-1 and specific genetic polymorphisms in predicting anthracycline-induced cardiotoxicity and endothelial dysfunction.
Cardiovascular disease remains the leading cause of mortality accounting up to 40% of all deaths, but, currently, cancer is prominent cause of death globally. Anthracyclines are the cornerstone of chemotherapy in women with breast cancer. However, its clinical use is limited by their cardiotoxic effects that can trigger heart failure development. Vascular toxicity of chemotherapy may be linked with endothelial dysfunction because anthracycline damage of endothelial cells can lead to the development and progression of cardiomyopathy by decreasing the release and activity of endothelial factors and, ultimately, endothelial cell death. These processes suppress anti-inflammatory and vascular reparative functions and initiate the development of future cardiovascular events. Recent studies have shown that chemotherapy may induce toxicity in the vascular endothelium and is accompanied by systemic endothelial dysfunction in patients with diagnosed cardiovascular diseases. Because the initial endothelial cell insult is likely asymptomatic, there is often a long delay between the termination of doxorubicin therapy and the onset of vascular disorders. In this case, genetic susceptibility factor will help to identify susceptible patients in the future. The objectives of this study were to evaluate prognostic role of molecular (endothelin-1) and genetic factors (gene polymorphisms of endothelial nitric oxide (NO) synthase (NOS3, rs1799983), endothelin-1 receptor type A (EDNRA, C+70G, rs5335) and NADPH oxidase (C242T, rs4673) in development of endothelial dysfunction and anthracycline-induced cardiotoxicity in women without cardiovascular diseases.
Гракова et al. (Fri,) conducted a observational in Anthracycline-induced cardiotoxicity. Molecular and genetic factors (endothelin-1, NOS3, EDNRA, NADPH oxidase polymorphisms) was evaluated on Development of endothelial dysfunction and anthracycline-induced cardiotoxicity. The abstract outlines the study objectives to evaluate the prognostic role of molecular and genetic factors in anthracycline-induced cardiotoxicity, but reports no results.