Higher HFpEF probability by HFA-PEFF and H2FPEF scores was associated with increased risk of HF readmissions and all-cause mortality (HR 1.16; 95% CI 1.02-1.32 per 0.10 increase in H2FPEF).
Cohort (n=443)
Do HFA-PEFF and H2FPEF diagnostic scores predict morbidity and mortality in patients hospitalized for heart failure with preserved ejection fraction?
Higher HFA-PEFF and H2FPEF diagnostic scores are associated with increased risk of subsequent HF readmissions and all-cause mortality in patients hospitalized with HFpEF.
Effect estimate: HR 1.16 (95% CI 1.02-1.32)
p-value: p=<0.001
Aims To investigate the prognostic value of diagnostic scores for heart failure (HF) with preserved ejection fraction (HFpEF). Methods and results Consecutive patients with HFpEF admitted for unequivocal decompensated HF treated with intravenous loop diuretics were evaluated ( n = 443; mean age 78 ± 12 years; 60% women). The HFA‐PEFF and H 2 FPEF scores were calculated for all patients with echocardiography data available within 1 year and the population was stratified according to HFA‐PEFF scores 2–4 ( n = 79), 5 ( n = 93), or 6 ( n = 271) and H 2 FPEF score probabilities <90% ( n = 80), 90–95% ( n = 61), and 96–100% ( n = 293). HF readmission rates (95% confidence intervals) increased from 28.9 (22.7–35.0) per 100 patient‐years in HFA‐PEFF 2–4 to 46.0 (38.5–53.5) in HFA‐PEFF 5 and 45.0 (40.1–49.8) in HFA‐PEFF 6. Similarly, HF readmission rates increased with increasing H 2 FPEF probability: <0.90 31.8 (25.3–38.2) per 100 patient‐years, 0.90–0.95 41.5 (32.9–50.1), and 0.96–1.00 45.9 (41.2–50.6. Median survival was 65 months (36–89 months) in HFA‐PEFF score 2–4, 45 months (26–59 months) in HFA‐PEFF score 5, and 28 months (22–42 months) in HFA‐PEFF score 6 ( P < 0.001), while the hazard ratio (95% confidence interval) for all‐cause mortality was 1.16 (1.02–1.32) per 0.10 increase in H 2 FPEF probability. Conclusions Among patients hospitalized with HFpEF, higher HFpEF probability according to diagnostic scores is associated with increased risk of subsequent HF readmissions and all‐cause mortality.
Verbrugge et al. (Fri,) conducted a cohort in Heart failure with preserved ejection fraction (HFpEF) (n=443). HFA-PEFF and H2FPEF diagnostic scores vs. Lower score categories was evaluated on HF readmissions and all-cause mortality (HR 1.16, 95% CI 1.02-1.32, p=<0.001). Higher HFpEF probability by HFA-PEFF and H2FPEF scores was associated with increased risk of HF readmissions and all-cause mortality (HR 1.16; 95% CI 1.02-1.32 per 0.10 increase in H2FPEF).