Therapeutic anticoagulation with enoxaparin followed by apixaban resulted in the resolution of aortic valve vegetation and left ventricular thrombus in a patient with COVID-19-associated marantic endocarditis.
Case Report (n=1)
No
Therapeutic anticoagulation successfully resolved marantic endocarditis and left ventricular thrombus in a patient with COVID-19-associated hypercoagulability.
Coronavirus disease 2019 (COVID-19) has overwhelmed healthcare globally with millions of cases and over 2 million deaths worldwide. The hypercoagulable state associated with COVID-19 is a well-recognized complication that carries a poor prognosis. Marantic endocarditis, or non-bacterial thrombotic endocarditis (NBTE), is caused by a sterile vegetation on the cardiac valves resulting from the deposition of fibrin and platelet aggregates. It is highly associated with the hypercoagulable and acquired inflammatory states. Herein, we report a unique and rare case of COVID-19 presenting with NBTE. LEARNING POINTS: COVID-19 has caused a major global pandemic, with high morbidity and mortality.One of the complications of COVID-19 infection is a hypercoagulable state.To the best of our knowledge, we present only the second case of marantic endocarditis in a patient with COVID-19, in the hope of raising awareness among physicians of this potential rare association.
Chan et al. (2021) conducted a case report in Marantic endocarditis (NBTE) associated with COVID-19 (n=1). Therapeutic anticoagulation (enoxaparin and apixaban) was evaluated on Resolution of vegetation and left ventricle thrombus. Therapeutic anticoagulation with enoxaparin followed by apixaban resulted in the resolution of aortic valve vegetation and left ventricular thrombus in a patient with COVID-19-associated marantic endocarditis.