In adults aged 65 and older with atrial fibrillation, DOACs became the dominant anticoagulant prescribed by 2018 and demonstrated higher 5-year persistence (0.80) compared to warfarin (0.71).
Cohort (n=42,290)
Yes
What are the trends in anticoagulation prescribing and persistence in adults aged ≥65 with atrial fibrillation?
Anticoagulation use in older adults with AF has significantly increased from 2008 to 2018, driven by DOACs, which also demonstrate higher 5-year persistence than warfarin.
Absolute Event Rate: 0.8% vs 0.71%
Abstract Objective To describe patterns of anticogulation prescribing and persistence for those aged ≥65 years with atrial fibrillation (AF). Methods Descriptive cohort study using electronic general practice records of patients in England who attended a flu vaccination aged ≥65, and were diagnosed with AF between 2008-2018. Patients were stratified by 10 year age group and year of diagnosis. Proportion anticoagulated, type of anticoagulation (direct oral anticoagulant (DOAC) or Warfarin) initiated at diagnosis, and persistence with anticoagulation over time are reported. Results 42,290 patients (49% female), aged 65-74 (n=11,722), 75-84 (n=19,055) and 85+ (n=11,513) at AF diagnosis are included. Prescription of anticoagulation at diagnosis increased over the time period from 55% to 86% in people aged 65-74, from 54% to 86% in people aged 75-84 and from 27% to 75% in people aged 85 and over. No patients were prescribed DOACs as a first anticoagulation agent in 2008, by 201892% of new AF patients were started on DOACs. Survivor function for 5 year persistence for patients taking only a single type of anticoagulant was 0.80 (0.77:0.82) for DOACs and0.71(0.70:0.72) for warfarin, Survivor function for any anticoagulation at 5 years was0.79(0.78:0.81), 0.73(0.72:0.75), 0.58(0.59:0.64) for people aged 65-74, 75-84 and 85+ respectively. Conclusions Rates of anticoagulation for new AF in those aged ≥65 have increased from 2008 to 2018, over which time there has been a shift from initiating anticoaguation with warfarin to DOACs. Persistence with anticoagulation is higher in people on DOACs than on warfarin, and in people under the aged of 85. Key Messages What is already known? Anticoagulation is a highly effective way of reducing the risk of stroke associated with AF, but is underused, particularly in older people. The introduction of DOACs has been associated with increasing use of anticoagulation in AF. What does this study add? Our study provides up to date information on anticoagulation for AF in older people who are most at risk of AF related stroke and highlights particular increases in use of anticoagulation in people aged 85 and over. DOACs are now the major class of anticoagulant prescribed to patients with new AF in UK general practice. Long term persistence with anticoagulation is higher with DOACs than warfarin, but drops in all age groups over 5 years. How might this impact on clinical practice? Improved uptake of anticoagulation at all ages removes one of the potential barriers to screening for atrial fibrillation, but new strategies may be needed to enhance longer term persistence with treatment.
Lund et al. (Mon,) conducted a cohort in Atrial fibrillation (n=42,290). Direct oral anticoagulants (DOACs) vs. Warfarin was evaluated on 5-year persistence with anticoagulation (95% CI 0.77-0.82). In adults aged 65 and older with atrial fibrillation, DOACs became the dominant anticoagulant prescribed by 2018 and demonstrated higher 5-year persistence (0.80) compared to warfarin (0.71).