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on AMP-hydrogels compared with control hydrogels during the first 3 days of infection. Studies performed on human whole blood showed that blood coagulated more readily in the presence of AMP-hydrogels as compared to hydrogels without AMPs, indicating potential hemostatic activity. Overall, the results suggest that the combination of amphiphilic hydrogels with covalently bonded AMPs has potential to be used as antibacterial wound dressing material to reduce infections and promote hemostatic activity as an alternative to antibiotics or other antimicrobial agents, whose use should be restricted.
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Saba Atefyekta
Edvin Blomstrand
Anand K. Rajasekharan
ACS Biomaterials Science & Engineering
Uppsala University
University of Gothenburg
Northeastern University
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Atefyekta et al. (Mon,) studied this question.
www.synapsesocial.com/papers/6a06f21a964d5135c0d3dff3 — DOI: https://doi.org/10.1021/acsbiomaterials.1c00029