April 1, 2021Open Access

Two-year outcomes of more than 30 000 elderly patients with atrial fibrillation: results from the All Nippon AF In the Elderly (ANAFIE) Registry

Structured PICO

Do DOACs reduce stroke/SEE, major bleeding, and all-cause death compared to well-controlled warfarin in elderly patients with NVAF?

Population

More than 30,000 elderly and very elderly patients with non-valvular atrial fibrillation (NVAF) in Japan

Intervention

Direct oral anticoagulants (DOACs)

Comparator

Well-controlled warfarin

Outcome

Stroke/systemic embolic event (SEE), major bleeding, and all-cause deathhard clinical

In a large Japanese registry of elderly NVAF patients, DOAC use was associated with lower rates of stroke, major bleeding, and mortality compared to well-controlled warfarin.

Abstract

In Japan, a large proportion of elderly and very elderly NVAF patients were receiving DOACs, which was significantly associated with lower rates of stroke/SEE, major bleeding, and all-cause death vs. well-controlled warfarin. History of falls and of catheter ablation were independently associated with stroke/SEE, major bleeding, and all-cause death.

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