What is the clinical evidence from this study?

Study design: Cohort. Population: Metabolic syndrome and Obstructive sleep apnea syndrome (n=10113560). Intervention: Metabolic syndrome vs. Absence of metabolic syndrome. Primary outcome: Incidence of obstructive sleep apnea syndrome (OSAS) (HR 1.50, 95% CI 1.52-1.57, p=<0.0001).

April 22, 2021Open Access

The relationship between metabolic syndrome and obstructive sleep apnea syndrome: a nationwide population-based study

Q: What are the key findings of this study?

Metabolic syndrome was significantly associated with an increased risk of incident obstructive sleep apnea syndrome (HR 1.50), with the risk increasing as the number of metabolic syndrome components increased.

DKDo Hyun KimSeoul St. Mary's Hospital BKBongseong KimSoongsil University KHKyungdo HanPreventive Cardiology

Key Result

Metabolic syndrome was significantly associated with an increased risk of incident obstructive sleep apnea syndrome (HR 1.50), with the risk increasing as the number of metabolic syndrome components increased.

Study Design

Type

Cohort (n=10,113,560)

Structured PICO

Does metabolic syndrome increase the risk of incident obstructive sleep apnea syndrome in adults?

Population

10,113,560 Korean adults aged >19 years were followed for up to 10 years to evaluate the association between metabolic syndrome and the incidence of obstructive sleep apnea syndrome.

Exposure

Presence of Metabolic Syndrome (MetS) and its individual components

Comparator

Absence of Metabolic Syndrome (non-MetS)

Outcome

Incidence of Obstructive Sleep Apnea Syndrome (OSAS)

Metabolic syndrome and its individual components, particularly increased waist circumference and triglycerides, are independently associated with a significantly higher risk of developing obstructive sleep apnea syndrome.

Main Result

Hazard Ratio: 1.5 (95% CI 1.52–1.57)

Absolute Event Rate: 1.16% vs 0.82%

p-value: p=<0.0001

Limitations

Risk of misclassification due to the use of claims data
Potential unmeasured confounding factors may exist and affect data quality
Causality could not be inferred due to the observational study design

Abstract

There has been a need for research on the association between metabolic syndrome (MetS) and obstructive sleep apnea syndrome (OSAS) using large data such as nationwide population-based data that adjusts important confounding factors. Therefore, we investigated the relationship between MetS and OSAS. The data source we used was the National Health Insurance Service claims database managed by the Republic of Korea government, in which 10,113,560 individuals were enrolled in 2009 and followed up until 2018. The independent association of MetS with the risk of OSAS was determined using a Cox proportional hazards model with adjustment for age, sex, smoking status, alcohol consumption, regular physical exercise, and body mass index. Our results showed that MetS were strongly associated to OSAS which was adjusted for several confounding factors. Also, we found men, increased waist circumference and increased triglyceride are important risk factors for OSAS.

Ask AI

Helpful

Bookmark

View Full Paper

Ask AI

Helpful

Bookmark

View Full Paper

Cite This Study

Kim et al. (Thu,) conducted a cohort in Metabolic syndrome and Obstructive sleep apnea syndrome (n=10,113,560). Metabolic syndrome vs. Absence of metabolic syndrome was evaluated on Incidence of obstructive sleep apnea syndrome (OSAS) (HR 1.50, 95% CI 1.52-1.57, p=<0.0001). Metabolic syndrome was significantly associated with an increased risk of incident obstructive sleep apnea syndrome (HR 1.50), with the risk increasing as the number of metabolic syndrome components increased.

synapsesocial.com/papers/6a221e9d3081c2f8f8e244d0 https://doi.org/https://doi.org/10.1038/s41598-021-88233-4

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: