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Abstract An organoselenium‐enabled radical relay Azidation‐carbocyclization reaction for the preparation of azide‐substituted quinoline‐2,4‐diones was developed. A series of previously unknown structurally diverse azide‐ substituted quinoline‐2,4‐diones were obtained under metal‐free and room‐temperature conditions. The key features of this reaction are a broad substrate scope, amenability to gram‐scale synthesis, and easy product derivatization. Preliminary mechanistic studies support participation of an organoselenium species in a radical relay pathway. magnified image
Wang et al. (Thu,) studied this question.
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