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Vadadustat, as compared with darbepoetin alfa, met the prespecified noninferiority criterion for hematologic efficacy but not the prespecified noninferiority criterion for cardiovascular safety in patients with NDD-CKD. (Funded by Akebia Therapeutics and Otsuka Pharmaceutical; PRO2TECT ClinicalTrials.gov numbers, NCT02648347 and NCT02680574.).
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Glenn M. Chertow
Pablo E. Pérgola
Youssef M.K. Farag
New England Journal of Medicine
Stanford University
Johns Hopkins University
Emory University
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Chertow et al. (Wed,) studied this question.
www.synapsesocial.com/papers/69d733a13f2a6ac123b8a54a — DOI: https://doi.org/10.1056/nejmoa2035938