High epicardial adipose tissue in patients with acute myocardial infarction was associated with a significantly larger infarct size at 12 weeks compared to low epicardial adipose tissue.
Observational (n=66)
No
Is high epicardial adipose tissue volume associated with greater myocardial damage (MVO, infarct size, reduced MSI) in patients with acute MI undergoing PCI?
In patients with acute MI, higher epicardial adipose tissue volume is associated with greater microvascular obstruction and larger infarct size at 12 weeks.
Absolute Event Rate: 23% vs 10%
p-value: p=<0.001
Abstract Aims Epicardial adipose tissue (EAT) has been linked to impaired reperfusion success after percutaneous coronary intervention (PCI). Whether EAT predicts myocardial damage in the early phase after acute myocardial infarction (MI) is unclear. Therefore, we investigated whether EAT in patients with acute MI is associated with more microvascular obstruction (MVO), greater ST-deviation, larger infarct size and reduced myocardial salvage index (MSI). Methods and results This retrospective analysis of a prospective observational study including patients with acute MI ( n = 54) undergoing PCI and 12 healthy matched controls. EAT, infarct size and MSI were analyzed with cardiac magnetic resonance imaging, conducted 3–5 days and 12 weeks after MI. Patients with acute MI showed higher EAT volume than healthy controls (46 25.;75. percentile: 37;59 vs. 24 15;29 ml, p < 0.001). The high EAT group (above median) showed significantly more MVO (2.22 0.00;5.38 vs. 0.0 0.00;2.18 %, p = 0.004), greater ST-deviation (0.38 0.22;0.55 vs. 0.15 0.03;0.20 mV×10 −1 , p = 0.008), larger infarct size at 12 weeks (23 17;29 vs. 10 4;16 %, p < 0.001) and lower MSI (40 37;54 vs. 66 49;88 %, p < 0.001) after PCI than the low EAT group. After accounting for demographic characteristics, body-mass index, heart volume, infarct location, TIMI-flow grade as well as apnea–hypopnea index, EAT was associated with infarct size at 12 weeks (B = 0.38 0.11;0.64, p = 0.006), but not with MSI. Conclusions Patients with acute MI showed higher volume of EAT than healthy individuals. High EAT was linked to more MVO and greater ST-deviation. EAT was associated with infarct size, but not with MSI. Graphic abstract
Fisser et al. (Wed,) conducted a observational in Acute myocardial infarction (n=66). High epicardial adipose tissue (≥46 ml) vs. Low epicardial adipose tissue (<46 ml) was evaluated on Infarct size at 12 weeks (%) (p=<0.001). High epicardial adipose tissue in patients with acute myocardial infarction was associated with a significantly larger infarct size at 12 weeks compared to low epicardial adipose tissue.