Baseline visceral adipose tissue (OR 1.16; 95% CI 1.12-2.31) and its increase over 5 years (OR 1.55) were associated with incident metabolic syndrome independent of BMI category.
Cohort
Are baseline and increases in visceral adipose tissue and insulin resistance associated with incident metabolic syndrome independent of obesity status?
Baseline levels and increases over time in visceral adipose tissue and insulin resistance are associated with incident metabolic syndrome independent of BMI category.
Effect estimate: OR 1.16 (95% CI 1.12-2.31)
OBJECTIVE: Although increasing evidence suggests that visceral adipose tissue (VAT) is a major underlying cause of metabolic syndrome (MetS), few studies have measured VAT at multiple time points in diverse populations. VAT and insulin resistance were hypothesized to differ by MetS status within BMI category in the Insulin Resistance Atherosclerosis Study (IRAS) Family Study and, further, that baseline VAT and insulin resistance and increases over time are associated with incident MetS. METHODS: Generalized estimating equations were used for differences in body fat distribution and insulin resistance by MetS status. Mixed effects logistic regression was used for the association of baseline and change in adiposity and insulin resistance with incident MetS across 5 years, adjusted for age, sex, race/ethnicity, and family correlation. RESULTS: VAT and insulin sensitivity differed significantly by MetS status and BMI category at baseline. VAT and homeostatic model assessment of insulin resistance (HOMA-IR) at baseline (VAT odds ratio OR = 1.16 95% CI: 1.12-2.31; HOMA-IR OR = 1.85 95% CI: 1.32-2.58) and increases over time (VAT OR = 1.55 95% CI: 1.22-1.98; HOMA-IR OR = 3.23 95% CI: 2.20-4.73) were associated with incident MetS independent of BMI category. CONCLUSIONS: Differing levels of VAT may be driving metabolic heterogeneity within BMI categories. Both overall and abdominal obesity (VAT) may play a role in the development of MetS. Increased VAT over time contributed additional risk.
Mongraw‐Chaffin et al. (Mon,) conducted a cohort in Metabolic Syndrome. Visceral adipose tissue (VAT) and insulin resistance was evaluated on Incident metabolic syndrome (OR 1.16, 95% CI 1.12-2.31). Baseline visceral adipose tissue (OR 1.16; 95% CI 1.12-2.31) and its increase over 5 years (OR 1.55) were associated with incident metabolic syndrome independent of BMI category.