The rs2074192 (ACE2), rs1799752 (ACE1), and rs699 (AGT) polymorphisms were significantly associated with symptomatic COVID-19, with the rs2074192 T/T genotype in males strongly predicting symptomatic status (OR 15.79).
Observational (n=104)
No
Do RAAS polymorphisms (ACE1, ACE2, AGT, AGTR1) predict symptomatic versus asymptomatic clinical outcomes in patients with SARS-CoV-2 infection?
Specific RAAS polymorphisms (rs2074192, rs1799752, and rs699) may predict the clinical severity of SARS-CoV-2 infection.
Odds Ratio: 15.79 (95% CI 1.9–131.47)
valor p: p=0.0019
Introduction: The renin–angiotensin–aldosterone system (RAAS), a metabolic cascade regulating pressure and circulating blood volume, has been considered the main system involved in the pathogenesis of severe lung injury and organs decline in COVID-19 patients. The angiotensin I-converting enzyme ( ACE1 ), angiotensin-converting enzyme 2 ( ACE2 ), angiotensinogen (AGT) and receptors angiotensin II receptor type 1 ( AGTR1 ) are key factors for SARS-CoV-2 entering in the cells, sodium and water retention with an increase blood pressure, promotion of fibrotic and inflammatory phenomena resulting in a cytokine storm. Methods: In this pilot study, the frequencies of six polymorphisms in the ACE1, ACE2, AGT and AGTR1 genes were analysed in symptomatic patients affected by COVID-19 and compared with the results obtained from asymptomatic subjects. Results: Thus, we have identified that rs2074192 ( ACE2 ), rs1799752 ( ACE1 ) and rs699 ( AGT ) SNPs could potentially be a valuable tool for predicting the clinical outcome of SARS-CoV-2 infected patients. A genetic predisposition may be prospected for severe internal organ damages and poor prognosis in patients with COVID-19 disease, as observed in symptomatic vs asymptomatic. Conclusion: This study provides evidence that analysis of RAAS polymorphisms could be considered the key point in understanding and predicting the SARS-CoV-2 course infection. Keywords: ACE , AGT , AGTR1 , RAAS, polymorphisms, SARS-CoV-2, asymptomatic, COVID-19
Cafiero et al. (Sat,) conducted a observational in SARS-CoV-2 infection (COVID-19) (n=104). RAAS polymorphisms (ACE1, ACE2, AGT, AGTR1) vs. Reference genotypes / Asymptomatic infection was evaluated on rs2074192 T/T genotype frequency in symptomatic vs asymptomatic males (codominant model) (OR 15.79, 95% CI 1.90-131.47, p=0.0019). The rs2074192 (ACE2), rs1799752 (ACE1), and rs699 (AGT) polymorphisms were significantly associated with symptomatic COVID-19, with the rs2074192 T/T genotype in males strongly predicting symptomatic status (OR 15.79).