Impaired heart rate variability (HRVI < 15) was independently associated with the presence of silent brain infarcts in atrial fibrillation patients presenting in sinus rhythm (OR 1.67).
Cohort (n=1,358)
Yes
Does impaired heart rate variability associate with silent brain infarcts in patients with atrial fibrillation?
Impaired heart rate variability is associated with the presence and larger volume of silent brain infarcts in patients with atrial fibrillation presenting in sinus rhythm.
Effect estimate: OR 1.67 (95% CI 1.03-2.70)
p-value: p=0.037
Purpose: Silent brain infarcts (SBI) are frequently detected in patients with atrial fibrillation (AF), but it is unknown whether SBI are linked to autonomic dysfunction. We aimed to explore the association of autonomic dysfunction with SBI in AF patients.Methods: 1,358 AF patients without prior stroke or TIA underwent brain MRI and 5-min resting ECG. We divided our cohort into AF patients who presented in sinus rhythm (SR-group, n = 816) or AF (AF-group, n = 542). HRV triangular index (HRVI), standard deviation of normal-to-normal intervals, mean heart rate, root mean square root of successive differences of normal-to-normal intervals, 5-min total power and power in the low frequency, high frequency and very low frequency range were calculated. Primary outcome was presence of SBI in the SR group, defined as large non-cortical or cortical infarcts. Secondary outcomes were SBI volumes and topography.Results: Mean age was 72 ± 9 years, 27% were female. SBI were detected in 10.5% of the SR group and in 19.9% of the AF group (p 0.001). HRVI 15 was the only HRV parameter associated with the presence of SBI after adjustment for clinical covariates in the SR group odds ratio (OR) 1.67; 95% confidence interval (CI): 1.03–2.70; p = 0.037. HRVI 15 was associated with larger brain infarct volumes β (95% CI) −0.47 (−0.84; −0.09), p = 0.016 in the SR group and was more frequently observed in patients with right- than left-hemispheric SBI (p = 0.017).Conclusion: Impaired HRVI is associated with SBI in AF patients. AF patients with autonomic dysfunction might undergo systematic brain MRI screening to initiate intensified medical treatment.Clinical Trials Gov Identifier: NCT02105844.
Hämmerle et al. (Fri,) conducted a cohort in Atrial Fibrillation (n=1,358). Impaired heart rate variability (HRVI < 15) vs. Normal heart rate variability (HRVI ≥ 15) was evaluated on Presence of silent brain infarcts (SBI) in the sinus rhythm group (OR 1.67, 95% CI 1.03-2.70, p=0.037). Impaired heart rate variability (HRVI < 15) was independently associated with the presence of silent brain infarcts in atrial fibrillation patients presenting in sinus rhythm (OR 1.67).