May 26, 2021

Lenvatinib Targets FGF Receptor 4 to Enhance Antitumor Immune Response of Anti–Programmed Cell Death‐1 in HCC

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Abstract

Lenvatinib reduced tumor PD-L1 level and Treg differentiation to improve anti-PD-1 efficacy by blocking FGFR4. Levels of FGFR4 expression and Treg infiltration in tumor could serve as biomarkers for screening patients with HCC using lenvatinib plus anti-PD-1 combination therapy.

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Authors

Chenhe Yi

Huashan Hospital

Lirong Chen

Jiangnan University

Zhifei Lin

Jiangsu Hengrui Medicine (China)

Journals

Hepatology

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Fudan University

Huashan Hospital

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Cite this study

Yi et al. (Wed,) studied this question.

synapsesocial.com/papers/69df2b39d85e58e37b7a18fe — DOI: https://doi.org/10.1002/hep.31921

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Also consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

Perforin and granzymes: function, dysfunction and human pathology· 2015 · 1,278 citations
Hippo Kinases Mst1 and Mst2 Sense and Amplify IL-2R-STAT5 Signaling in Regulatory T Cells to Establish Stable Regulatory Activity· 2018 · 112 citations
IL‐10 producing type 2 innate lymphoid cells prolong islet allograft survival· 2020 · 44 citations
Revisiting IL-2: Biology and therapeutic prospects· 2018 · 631 citations
FOXP3+ regulatory T cells in the human immune system· 2010 · 2,412 citations

Lenvatinib Targets FGF Receptor 4 to Enhance Antitumor Immune Response of Anti–Programmed Cell Death‐1 in HCC

Key Points

Abstract

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Authors

Journals

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Institutions

References and Citations

Citation Network

Connected Papers

Discussion

Cite this study

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