Toll-like receptors are increasingly implicated in the pathophysiology of viral myocarditis, profoundly affecting every stage of the disease process through innate and adaptive immune responses.
This review highlights the central role of Toll-like receptors in the innate and adaptive immune responses during viral myocarditis, suggesting them as prime candidates affecting the disease process.
Myocarditis is an inflammatory disease of the heart with viral infections being the most common aetiology. Its complex biology remains poorly understood and its clinical management is one of the most challenging in the field of cardiology. Toll-like receptors (TLRs), a family of evolutionarily conserved pattern recognition receptors, are increasingly known to be implicated in the pathophysiology of viral myocarditis. Their central role in innate and adaptive immune responses, and in the inflammatory reaction that ensues, indeed makes them prime candidates to profoundly affect every stage of the disease process. This review describes the pathogenesis and pathophysiology of viral myocarditis, and scrutinises the role of TLRs in every phase. We conclude with directions for future research in this field.
Favere et al. (Thu,) conducted a review in Viral myocarditis. Toll-like receptors (TLRs) was evaluated. Toll-like receptors are increasingly implicated in the pathophysiology of viral myocarditis, profoundly affecting every stage of the disease process through innate and adaptive immune responses.