A deep-learning-based ECG analysis system addressed unmet clinical needs by providing visual explanations, uncertainty estimation, and handling unknown rhythm types in simulated large-scale screening.
This study presents a deep-learning ECG analysis system that addresses key clinical barriers to AI adoption by providing explainability, uncertainty estimation, and the ability to handle unknown medical conditions.
Despite their great promise, artificial intelligence (AI) systems have yet to become ubiquitous in the daily practice of medicine largely due to several crucial unmet needs of healthcare practitioners. These include lack of explanations in clinically meaningful terms, handling the presence of unknown medical conditions, and transparency regarding the system's limitations, both in terms of statistical performance as well as recognizing situations for which the system's predictions are irrelevant. We articulate these unmet clinical needs as machine-learning (ML) problems and systematically address them with cutting-edge ML techniques. We focus on electrocardiogram (ECG) analysis as an example domain in which AI has great potential and tackle two challenging tasks: the detection of a heterogeneous mix of known and unknown arrhythmias from ECG and the identification of underlying cardio-pathology from segments annotated as normal sinus rhythm recorded in patients with an intermittent arrhythmia. We validate our methods by simulating a screening for arrhythmias in a large-scale population while adhering to statistical significance requirements. Specifically, our system 1) visualizes the relative importance of each part of an ECG segment for the final model decision; 2) upholds specified statistical constraints on its out-of-sample performance and provides uncertainty estimation for its predictions; 3) handles inputs containing unknown rhythm types; and 4) handles data from unseen patients while also flagging cases in which the model's outputs are not usable for a specific patient. This work represents a significant step toward overcoming the limitations currently impeding the integration of AI into clinical practice in cardiology and medicine in general.
Elul et al. (Mon,) conducted a other in Arrhythmias. Deep-learning-based ECG analysis system was evaluated on Detection of known and unknown arrhythmias and identification of underlying cardio-pathology from normal sinus rhythm segments. A deep-learning-based ECG analysis system addressed unmet clinical needs by providing visual explanations, uncertainty estimation, and handling unknown rhythm types in simulated large-scale screening.