Only 50.9% of acute myocardial infarction hospital admissions in patients with a prior cancer diagnosis were captured in both MINAP and HES databases, indicating the need for multiple linked data sources.
Cohort (n=95,509)
Yes
Relying on a single electronic health record database misses a substantial portion of acute myocardial infarction cases in cancer patients, highlighting the necessity of using linked data sources for cardio-oncology research.
AIMS: To assess the recording and accuracy of acute myocardial infarction (AMI) hospital admissions between two electronic health record databases within an English cancer population over time and understand the factors that affect case-ascertainment. METHODS AND RESULTS: We identified 112 502 hospital admissions for AMI in England 2010-2017 from the Myocardial Ischaemia National Audit Project (MINAP) disease registry and hospital episode statistics (HES) for 95 509 patients with a previous cancer diagnosis up to 15 years prior to admission. Cancer diagnoses were identified from the National Cancer Registration Dataset (NCRD). We calculated the percentage of AMI admissions captured by each source and examined patient characteristics associated with source of ascertainment. Survival analysis assessed whether differences in survival between case-ascertainment sources could be explained by patient characteristics. A total of 57 265 (50.9%) AMI admissions in patients with a prior diagnosis of cancer were captured in both MINAP and HES. Patients captured in both sources were younger, more likely to have ST-segment elevation myocardial infarction and had better prognosis, with lower mortality rates up to 9 years after AMI admission compared with patients captured in only one source. The percentage of admissions captured in both data sources improved over time. Cancer characteristics (site, stage, and grade) had little effect on how AMI was captured. CONCLUSION: MINAP and HES define different populations of patients with AMI. However, cancer characteristics do not substantially impact on case-ascertainment. These findings support a strategy of using multiple linked data sources for observational cardio-oncological research into AMI.
Coles et al. (Mon,) conducted a cohort in Acute myocardial infarction in patients with previous cancer (n=95,509). Electronic health record database (MINAP and HES) vs. Single database ascertainment was evaluated on Proportion of AMI admissions captured in both MINAP and HES databases. Only 50.9% of acute myocardial infarction hospital admissions in patients with a prior cancer diagnosis were captured in both MINAP and HES databases, indicating the need for multiple linked data sources.