The AL-c/HDL-c ratio was significantly increased in STEMI patients compared to healthy adults and served as an independent predictor of STEMI with an odds ratio of 2.231.
Case-Control (n=750)
No
Does the AL-c/HDL-c ratio improve the prediction of STEMI compared to RLP-c alone in adults?
The AL-c/HDL-c ratio is a sensitive and independent biomarker for predicting STEMI risk, outperforming traditional lipid markers like LDL-c and RLP-c alone.
Absolute Event Rate: 0.93% vs 0.7%
p-value: p=<0.001
The detectable component of triglyceride-rich lipoproteins (TGRLs), remnant lipoprotein cholesterol (RLP-c), has been proven being correlated with the progression of atherosclerosis and myocardial infarction. However, when taken as a risk predictor, the prognostic and diagnostic potential of RLP-c remains controversial in studies. In this study, we evaluated the hypothesis that atherogenic lipoprotein-cholesterol (AL-c), representing the sum of RLP-c and the sd-LDL-c, to the HDL-c ratio, could represent a better predictive indicator than RLP-c alone in ST-segment elevation myocardial infarction (STEMI). Methods: The 316 consecutive patients suffering from persistent chest discomfort admitted to the Shanghai General Hospital between January 2018 and June 2018 were enrolled. 149 STEMI patients (62% men, mean age 69.6 13.3 years) were included as the study cohort. The AL-c/HDL-c ratio was calculated on admission in a cohort of electrocardiogram-confirmed STEMI patients and compared to other lipid profiles as a predictive indicator.
Li et al. (Fri,) conducted a case-control in ST-segment elevation myocardial infarction (STEMI) (n=750). AL-c/HDL-c ratio vs. Apparently healthy adults was evaluated on AL-c/HDL-c ratio (p=<0.001). The AL-c/HDL-c ratio was significantly increased in STEMI patients compared to healthy adults and served as an independent predictor of STEMI with an odds ratio of 2.231.