Acute kidney injury increased 28-day mortality in STEMI patients without CKD (OR 3.24; 95% CI 1.46-7.18) and with CKD (OR 4.57; 95% CI 1.83-11.37) compared to those without AKI or CKD.
Cohort (n=1,031)
Does acute kidney injury increase the risk of short-term mortality in patients with STEMI?
Comorbid AKI significantly increases the risk of 28-day mortality in patients with STEMI, particularly when superimposed on chronic kidney disease.
Odds Ratio: 3.24 (95% CI 1.46–7.18)
Acute myocardial infarction (AMI) in patients with acute kidney injury (AKI) is associated with poor long-term outcome. However, the short-term prognosis of AKI in patients with ST-elevation AMI (STEMI) needs to be explored further. We assessed this relationship between these patients and short-term mortality in relation to AKI and chronic kidney disease (CKD). All data were extracted from the Medical Information Mart for Intensive Care III database. The primary outcome was 28-day mortality. Kaplan-Meier curves, logistic regression models, and propensity score matching analysis were used to evaluate the associations between AKI in patients with STEMI and outcomes. A total of 1031 patients with STEMI met the inclusion criteria. For 28-day mortality, in the multivariable logistic regression models, the odds ratio (95% CI) of group 2 (AKI but no CKD) and group 3 (AKI in the presence of CKD) were 3.24 (1.46-7.18) and 4.57 (1.83-11.37), respectively, compared with group 1 (no AKI and no CKD). Comorbid AKI increased the risk of short-term mortality among patients with STEMI, especially for those with AKI in the presence of CKD.
Meng et al. (2021) conducted a cohort in ST-elevation AMI (STEMI) (n=1,031). Acute kidney injury (AKI) vs. No AKI and no CKD was evaluated on 28-day mortality (OR 3.24, 95% CI 1.46-7.18). Acute kidney injury increased 28-day mortality in STEMI patients without CKD (OR 3.24; 95% CI 1.46-7.18) and with CKD (OR 4.57; 95% CI 1.83-11.37) compared to those without AKI or CKD.