Inactin anesthesia preserved sympathetic nerve activity and arterial blood pressure responses to renal stimuli, whereas these responses were largely absent with isoflurane, urethane, or decerebration.
The findings highlight the impact of anesthesia, and to a lesser extent sex, on sympathetic efferent and hemodynamic responses to chemosensory and mechanosensory renal stimuli. Sympathetic nerve activity (SNA) and arterial blood pressure (ABP) responses were present in Inactin-anesthetized rats but largely absent in decerebrate, isoflurane, or urethane preparations. Renal chemosensory stimuli differentially changed SNA: renal and splanchnic SNA increased, but lumbar SNA decreased. Future investigations should consider Inactin anesthesia to study SNA and hemodynamic responses to renal sensory nerve activation.
DeLalio et al. (Wed,) reported a other. Inactin anesthesia vs. Decerebrate, isoflurane, or urethane preparations was evaluated on Sympathetic nerve activity (SNA) and arterial blood pressure (ABP) responses. Inactin anesthesia preserved sympathetic nerve activity and arterial blood pressure responses to renal stimuli, whereas these responses were largely absent with isoflurane, urethane, or decerebration.