Is high adiposity a causal risk factor for cardiovascular outcomes?
This umbrella review and meta-analysis confirms that high adiposity is a causal risk factor for cardiovascular disease, with consistent associations across sexes and global regions.
High adiposity is associated with increased CVD risk despite divergent evidence gradients. Adiposity was a causal risk factor for CVD except all-cause mortality and stroke. Half (49%; 26/53) of the associations were supported by high-level evidence. The associations were consistent between sexes and across global regions. This study provides guidance on how to integrate evidence from observational (association) and genetics-driven (causation) studies accumulated to date, to enable a more reliable interpretation of epidemiological relationships.
Kim et al. (Tue,) studied this question.
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