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ColabFold is an easy-to-use Notebook based environment for fast and convenient protein structure predictions. Its structure prediction is powered by AlphaFold2 and RoseTTAFold combined with a fast multiple sequence alignment generation stage using MMseqs2. MMseqs2’s MSAs produce more accurate predictions while being ∼16 faster compared to the AlphaFold2’s MSA stage. ColabFold also offers many advanced features, such as homo- and hetero-complex modeling, and exposes AlphaFold2 internals. When coupled with Google Colab, ColabFold becomes a free and accessible platform for protein folding that does not require any installation or expensive hardware. Preprint: https://www.biorxiv.org/content/10.1101/2021.08.15.456425v1
Mirdita et al. (Thu,) studied this question.