Acute alcohol consumption was associated with higher odds of an AF episode, with an OR of 2.02 (95% CI 1.38-3.17) for 1 drink and 3.58 (95% CI 1.63-7.89) for ≥2 drinks in the preceding 4 hours.
Observational (n=100)
Does acute alcohol consumption trigger discrete atrial fibrillation events in patients with paroxysmal AF?
Acute alcohol consumption significantly increases the odds of a discrete atrial fibrillation event within the subsequent 4 hours in patients with paroxysmal AF.
Effect estimate: OR 2.02 (95% CI 1.38 to 3.17)
BACKGROUND: Patients' self-reports suggest that acute alcohol consumption may trigger a discrete atrial fibrillation (AF) event. OBJECTIVE: To objectively ascertain whether alcohol consumption heightens risk for an AF episode. DESIGN: A prospective, case-crossover analysis. SETTING: Ambulatory persons in their natural environments. PARTICIPANTS: Consenting patients with paroxysmal AF. MEASUREMENTS: Participants were fitted with a continuous electrocardiogram (ECG) monitor and an ankle-worn transdermal ethanol sensor for 4 weeks. Real-time documentation of each alcoholic drink consumed was self-recorded using a button on the ECG recording device. Fingerstick blood tests for phosphatidylethanol (PEth) were used to corroborate ascertainments of drinking events. RESULTS: Of 100 participants (mean age, 64 years SD, 15; 79% male; 85% White), 56 had at least 1 episode of AF. Results of PEth testing correlated with the number of real-time recorded drinks and with events detected by the transdermal alcohol sensor. An AF episode was associated with 2-fold higher odds of 1 alcoholic drink (odds ratio OR, 2.02 95% CI, 1.38 to 3.17) and greater than 3-fold higher odds of at least 2 drinks (OR, 3.58 CI, 1.63 to 7.89) in the preceding 4 hours. Episodes of AF were also associated with higher odds of peak blood alcohol concentration (OR, 1.38 CI, 1.04 to 1.83 per 0.1% increase in blood alcohol concentration) and the total area under the curve of alcohol exposure (OR, 1.14 CI, 1.06 to 1.22 per 4.7% increase in alcohol exposure) inferred from the transdermal ethanol sensor in the preceding 12 hours. LIMITATION: Confounding by other time-varying exposures that may accompany alcohol consumption cannot be excluded, and the findings from the current study of patients with AF consuming alcohol may not apply to the general population. CONCLUSION: Individual AF episodes were associated with higher odds of recent alcohol consumption, providing objective evidence that a modifiable behavior may influence the probability that a discrete AF event will occur. PRIMARY FUNDING SOURCE: National Institute on Alcohol Abuse and Alcoholism.
Marcus et al. (Mon,) conducted a observational in Paroxysmal atrial fibrillation (n=100). Acute alcohol consumption vs. Periods without recent alcohol consumption was evaluated on Atrial fibrillation episode (OR 2.02, 95% CI 1.38 to 3.17). Acute alcohol consumption was associated with higher odds of an AF episode, with an OR of 2.02 (95% CI 1.38-3.17) for 1 drink and 3.58 (95% CI 1.63-7.89) for ≥2 drinks in the preceding 4 hours.
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