Higher atherogenic index of plasma (AIP) levels predicted incident ischemic heart disease in non-diabetic Korean adults, with the highest quartile having an HR of 2.11 (95% CI, 1.37-3.24).
Cohort (n=17,944)
Does a higher Atherogenic Index of Plasma (AIP) predict the risk of incident ischemic heart disease in non-diabetic Korean adults?
The Atherogenic Index of Plasma (AIP) is an independent predictor of incident ischemic heart disease in non-diabetic adults, suggesting its utility as a cardiometabolic risk marker.
Estimación del efecto: HR 2.11 (95% CI 1.37-3.24)
The atherogenic index of plasma (AIP), composed of triglycerides and high-density lipoprotein cholesterol, is a novel critical marker for assessing the risk of atherogenicity and cardiometabolic health. We aimed to prospectively study the association between AIP and incident ischemic heart disease (IHD) risk in a large cohort of non-diabetic Korean adults. Data were assessed from 17,944 participants without diabetes from the Health Risk Assessment Study (HERAS) and Korea Health Insurance Review and Assessment (HIRA) data. The participants were divided into four groups according to AIP quartiles, calculated as log (triglyceride/high-density lipoprotein cholesterol). We prospectively assessed hazard ratios (HRs) with 95% confidence intervals (CIs) for IHD using multivariate Cox proportional-hazard regression models over a 50-month period that followed the baseline survey. During the follow-up period, 332 participants (1.9%) developed IHD. HRs of IHD for AIP quartiles 2-4 were 1.58 (95% CI, 1.03-2.43), 1.82 (95% CI, 1.20-2.78), and 2.11 (95% CI, 1.37-3.24) after adjusting for age, sex, body mass index, smoking status, alcohol intake, physical activity, mean arterial blood pressure, fasting plasma glucose, high-sensitivity C-reactive protein level, and hypertension medication. Higher AIP levels may precede and predict the development of IHD in non-diabetic Korean adults.
Kim et al. (Thu,) conducted a cohort in Incident ischemic heart disease (n=17,944). Atherogenic index of plasma (AIP) vs. Lowest AIP quartile was evaluated on Incident ischemic heart disease (IHD) (HR 2.11, 95% CI 1.37-3.24). Higher atherogenic index of plasma (AIP) levels predicted incident ischemic heart disease in non-diabetic Korean adults, with the highest quartile having an HR of 2.11 (95% CI, 1.37-3.24).