A TAPSE/sPAP ratio cut-off of ≤0.60 mm/mmHg yielded a higher positive predictive value for pulmonary arterial hypertension than the DETECT algorithm (62.5% vs 31.3%) in systemic sclerosis patients.
Cohort (n=51)
Does the TAPSE/sPAP ratio improve the positive predictive value for PAH diagnosis compared to the DETECT algorithm in patients with systemic sclerosis?
The TAPSE/sPAP ratio provides a higher positive predictive value than the DETECT algorithm for identifying PAH in systemic sclerosis patients, potentially reducing unnecessary right heart catheterizations.
Absolute Event Rate: 62.5% vs 31.3%
OBJECTIVE: Early detection of pulmonary arterial hypertension (PAH) is crucial for improving patient outcomes. The aim of this study was to compare the positive predictive value (PPV) of the echocardiography-derived tricuspid annular plane systolic excursion/systolic pulmonary artery pressure (TAPSE/sPAP) ratio with that of the DETECT algorithm for PAH screening in a cohort of SSc patients. METHODS: Fifty-one SSc patients were screened for PAH using the DETECT algorithm and echocardiography. RESULTS: Echocardiography was recommended by the DETECT algorithm step 1 in 34 patients (66.7%). Right heart catheterization (RHC) was recommended by the DETECT algorithm step 2 in 16 patients (31.4%). PAH was confirmed by RHC in 5 patients. The DETECT algorithm PPV was 31.3%. The TAPSE/sPAP ratio was higher in SSc patients not referred for RHC than in SSc patients referred for RHC according to the DETECT algorithm step 2 [0.83 (0.35-1.40) mm/mmHg vs 0.74 (0.12-1.09) mm/mmHg, P 35, the TAPSE/sPAP ratio can be used to further select patients requiring RHC to confirm PAH diagnosis.
Colalillo et al. (Fri,) conducted a cohort in Systemic sclerosis (SSc) (n=51). TAPSE/sPAP ratio vs. DETECT algorithm was evaluated on Positive predictive value (PPV) for PAH screening. A TAPSE/sPAP ratio cut-off of ≤0.60 mm/mmHg yielded a higher positive predictive value for pulmonary arterial hypertension than the DETECT algorithm (62.5% vs 31.3%) in systemic sclerosis patients.