Ideal cardiovascular health was associated with a 22.6% lifetime risk of type 2 diabetes at age 55, compared to 32.6% for poor cardiovascular health, regardless of genetic predisposition.
Cohort (n=5,993)
Does ideal cardiovascular health reduce the lifetime risk of type 2 diabetes regardless of genetic predisposition in middle-aged individuals?
Favorable cardiovascular health significantly reduces the lifetime risk of developing type 2 diabetes, regardless of an individual's genetic predisposition.
Absolute Event Rate: 22.6% vs 32.6%
AIMS: Data on the lifetime risk of type 2 diabetes (T2D) incidence across different cardiovascular health (CVH) categories are scarce. Moreover, it remains unclear whether a genetic predisposition modifies this association. METHODS AND RESULTS: Using data from the prospective population-based Rotterdam Study, a CVH score (body mass index, blood pressure, total cholesterol, smoking status, diet, and physical activity) was calculated and further categorized at baseline. Genetic predisposition to T2D was assessed and divided into tertiles by creating a genetic risk score (GRS). We estimated the lifetime risk for T2D within different CVH and GRS categories. Among 5993 individuals free of T2D at baseline mean (standard deviation) age, 69.1 (8.5) years; 58% female, 869 individuals developed T2D during follow-up. At age 55 years, the remaining lifetime risk of T2D was 22.6% (95% CI: 19.4-25.8) for ideal, 28.3% (25.8-30.8) for intermediate, and 32.6% (29.0-36.2) for poor CVH. After further stratification by GRS tertiles, the lifetime risk for T2D was still the lowest for ideal CVH in the lowest GRS tertiles 21.5% (13.7-29.3), in the second GRS tertile 20.8% (15.9-25.8), and in the highest tertile 23.5% (18.5-28.6) when compared with poor and intermediate CVH. CONCLUSION: Our results highlight the importance of favourable CVH in preventing T2D among middle-aged individuals regardless of their genetic predisposition.
Wang et al. (Tue,) conducted a cohort in Type 2 diabetes (n=5,993). Ideal cardiovascular health vs. Poor and intermediate cardiovascular health was evaluated on Lifetime risk of type 2 diabetes at age 55 years. Ideal cardiovascular health was associated with a 22.6% lifetime risk of type 2 diabetes at age 55, compared to 32.6% for poor cardiovascular health, regardless of genetic predisposition.