Each unit increase in log-transformed visceral adiposity index was associated with a 2.13-fold increased risk of high arterial stiffness (OR 2.13) in normal-weight adults with hypertension.
Cross-Sectional (n=3,258)
Is visceral adiposity index associated with increased arterial stiffness in normal-weight adults with hypertension?
Higher visceral adiposity index is independently associated with increased arterial stiffness in normal-weight hypertensive adults, highlighting a frequently overlooked cardiovascular risk factor in non-obese patients.
Odds Ratio: 2.13 (95% CI 1.59–2.86)
p-value: p=<0.001
BACKGROUND: Limited information is available on arterial stiffness risk among hypertensive patients with metabolically abnormal but normal weight. Visceral adiposity index (VAI) is a novel indicator for visceral fat mass and metabolism, however, whether can be used to assessed arterial stiffness in a normal-weight population remains unclear. The goal of this study was to examine the independent association of VAI with arterial stiffness in normal-weight hypertensive patients. METHODS: 3258 participants recruited from the China H-type Hypertension Registry Study. VAI value was calculated using sex-specific equations. High arterial stiffness was defined as baPWV ≥ 18 m/s. Multivariable regression analysis was used to identify the association of VAI with baPWV and high arterial stiffness. RESULTS: Of participants, 50.5% (1644) were males, the mean age was 65.5 (SD, 9.1) years. Mean VAI and baPWV were 2.0 (SD, 2.3) and 18.2 (SD, 3.9) m/s, respectively. For each unit increase of lg VAI in multivariable regression analysis, there was a 1.05 m/s increase in baPWV (95% CI 0.67, 1.43) and a 2.13-fold increase in the risk of high arterial stiffness (95% CI 1.59, 2.86). In all models, the VAI was consistently and significantly associated with baPWV after adjustment for different confounders. High VAI levels were stably associated with baPWV in all subgroups. CONCLUSIONS: We found positive association of VAI with baPWV and high arterial stiffness in normal-weight adults with hypertension. The establishment of this association could help the arterial stiffness risk stratification in normal-weight hypertensive populations, who are frequently overlooked in preventing cardiovascular disease.
Li et al. (Sat,) conducted a cross-sectional in Hypertension with normal weight (n=3,258). Visceral adiposity index (VAI) vs. Lower VAI levels was evaluated on High arterial stiffness (baPWV ≥ 18 m/s) (OR 2.13, 95% CI 1.59, 2.86, p=<0.001). Each unit increase in log-transformed visceral adiposity index was associated with a 2.13-fold increased risk of high arterial stiffness (OR 2.13) in normal-weight adults with hypertension.