Healthy humans with exceptional life span exhibit a unique plasma sphingolipidome with higher complex glycosphingolipids and lower ceramide species, sphingomyelin, and sulfatide.
Observational
A species-specific lipidome profile is an inherent feature linked to longevity in the animal kingdom. However, there is a lack of lipidomic studies on human longevity. Here, we use mass spectrometry-based lipidomics to detect and quantify 151 sphingolipid molecular species and use these to define a phenotype of healthy humans with exceptional life span. Our results demonstrate that this profile specifically comprises a higher content of complex glycosphingolipids (hexosylceramides and gangliosides), and lower levels of ceramide species from the de novo pathway, sphingomyelin and sulfatide; while for ceramide-derived signaling compounds, their content remains unchanged. Our findings suggest that structural glycosphingolipids may be more relevant to achieve the centenarian condition than signaling sphingolipids.
Pradas et al. (Sun,) conducted a observational in Exceptional life span / Longevity. Exceptional life span was evaluated on Plasma sphingolipidome profile. Healthy humans with exceptional life span exhibit a unique plasma sphingolipidome with higher complex glycosphingolipids and lower ceramide species, sphingomyelin, and sulfatide.