Dynamic reorganization of cardiac calcium channels and signaling proteins occurs alongside architectural remodeling and contributes to impaired contractile function.
This review highlights the critical role of nanoscale organization and dynamic reorganization of cardiac calcium channels (CaV1.2 and RyR2) in excitation-contraction coupling, and how their mis-regulation contributes to impaired contractility in heart failure.
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signaling proteins occurs alongside architectural remodeling and is thought to contribute to impaired contractile function. In the present review we discuss these latest developments, their implications, and future questions to be addressed.
Rose E. Dixon (Wed,) reported a other. Dynamic reorganization of cardiac calcium channels and signaling proteins occurs alongside architectural remodeling and contributes to impaired contractile function.