Serum Lipoprotein (a) levels were not significantly correlated with angiographic lesion severity in CAD patients, despite a median of 18.9 mg/dL in the severe group vs 13.7 mg/dL in the mild group.
Cross-Sectional (n=107)
Does serum Lp(a) level correlate with angiographic lesion severity in patients with CAD?
This study found no significant overall correlation between serum Lp(a) levels and angiographic lesion severity assessed by SYNTAX score in patients with CAD.
Absolute Event Rate: 18.9% vs 13.7%
Background: The several epidemiological and meta-analysis studies suggested that the elevated lipoprotein (a) (Lp(a)) level is associated to cause the coronary artery disease (CAD). However, the role of this pro-atherogenic Lp (a) in regulating the severity of angiographic lesions in CAD is poorly understood. This study aimed to estimate the serum Lp (a) level and find its correlation with angiographic lesion severity in subjects with CAD. Methods: In this cross-sectional study, a total of 107 subjects angiographic lesion severity was determined by SYNergy between percutaneous coronary interventions with TAXUS and cardiac surgery (SYNTAX) scoring system and grouped into mild (<22) and severe (≤22) based on the SYNTAX score. The serum Lp (a) concentration in subjects' serum was measured by immunoturbidimetric assay. Results: The median Lp (a) level of all subjects was found to be 14.8 mg/dL, it was higher in severe angiographic lesion group (18.9 mg/dL, interquartile range IQR: 12.3–24.4) when compared to mild group (13.7 mg/dL, IQR: 6.6–18.6). The Spearman correlation analysis revealed that the relationship between serum Lp (a) level and angiographic lesion severity in mild and severe subjects is not statistically significant except with the mild group female subjects. Conclusions: Overall, this study does not support the association of angiographic lesion severity with serum Lp (a) levels in CAD. To infer precisely, similar studies with more subjects are needed to confirm this study's findings.
Kulkarni et al. (Fri,) conducted a cross-sectional in Coronary Artery Disease (n=107). Serum Lipoprotein (a) was evaluated on Correlation between serum Lp(a) level and angiographic lesion severity (SYNTAX score). Serum Lipoprotein (a) levels were not significantly correlated with angiographic lesion severity in CAD patients, despite a median of 18.9 mg/dL in the severe group vs 13.7 mg/dL in the mild group.
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