Adults with uncomplicated obesity exhibited increased left ventricular size and mass, and impaired myocardial contractility with lower peak strains compared to healthy controls (P<0.05).
Cross-Sectional
Does uncomplicated obesity lead to subclinical left ventricular remodeling and dysfunction compared to healthy controls?
Uncomplicated obesity is associated with subclinical left ventricular remodeling and impaired myocardial contractility as detected by CMR, with visceral adipose tissue and insulin resistance serving as potential predictors of this dysfunction.
p-value: p=<0.05
Background: Obesity often exists alongside comorbidities and increases the risk of heart failure and cardiovascular mortality. However, the specific effects of obesity on cardiac structure and function have not been clarified. This study set out to evaluate left ventricular (LV) geometric and functional changes using cardiovascular magnetic resonance imaging (CMR) in adults with uncomplicated obesity. Methods: ] and 25 healthy controls were included in this study. CMR was used to assess LV geometry, global systolic function, and strains, and to quantify epicardial adipose tissue (EAT). Body composition was measured by dual X-ray absorptiometry. Results: Compared with healthy controls, patients with obesity had increased LV size, mass, and myocardial thickness, and impaired myocardial contractility, with lower global radial, circumferential, and longitudinal peak strains (PS), and circumferential and longitudinal peak diastolic strain rates (PDSR; all P<0.05). Multivariable linear regression showed that BMI was independently associated with LV maximum myocardial thickness (LVMMT) (β=0.197, P=0.016). Visceral adipose tissue (VAT) was independently associated with LV global longitudinal PS (β=-2.684, P=0.001), and both longitudinal (β=-0.192, P=0.002) and circumferential (β=-0.165, P=0.014) PDSR. Homeostasis model assessment of insulin resistance (HOMA-IR) was mildly correlated with BMI (r=0.327) and body fat percentage (BF%) (r=0.295) in patients with obesity (all P<0.05). HOMA-IR was independently associated with LV global circumferential PS (β=-0.276, P=0.04) and PDSR (β=-0.036, P=0.026). Conclusions: Extensive LV geometric remodeling and marked changes in cardiac strains were observed in adults with obesity. Tissue tracking with CMR can reveal subclinical impaired ventricular function with preserved LV ejection fraction in such patients. BMI was independently related to LV remodeling in obesity. HOMA-IR and VAT are potentially superior to BMI as predictors of subclinical dysfunction, assessed by strain, in obesity. Trial Registry: This study has been registered with the Chinese Clinical Trial Registry (ID: ChiCTR1900026476; Effect of lifestyle intervention on metabolism of obese patients based on smart phone software).
Liu et al. (Thu,) conducted a cross-sectional in Uncomplicated obesity. Obesity vs. Healthy controls was evaluated on Left ventricular geometric and functional changes (size, mass, myocardial thickness, and strains) (p=<0.05). Adults with uncomplicated obesity exhibited increased left ventricular size and mass, and impaired myocardial contractility with lower peak strains compared to healthy controls (P<0.05).